Accuracy of Whole-Genome Prediction Using a Genetic Architecture-Enhanced Variance-Covariance Matrix

Accuracy of Whole-Genome Prediction Using a Genetic Architecture-Enhanced Variance-Covariance Matrix

Obtaining accurate predictions of unobserved genetic or phenotypic values for complex traits in animal, plant, and human populations is possible through whole-genome prediction (WGP), a combined analysis of genotypic and phenotypic data. Because the underlying genetic architecture of the trait of interest is an important factor affecting model selection, we propose a new strategy, termed BLUP|G...

Accuracy of whole genome prediction using a genetic 1 architecture enhanced variance - covariance matrix

Determining the effective dimensionality of the genetic variance-covariance matrix.

Determining the dimensionality of G provides an important perspective on the genetic basis of a multivariate suite of traits. Since the introduction of Fisher's geometric model, the number of genetically independent traits underlying a set of functionally related phenotypic traits has been recognized as an important factor influencing the response to selection. Here, we show how the effective d...

Characterizing the evolution of genetic variance using genetic covariance tensors.

Determining how genetic variance changes under selection in natural populations has proved to be a very resilient problem in evolutionary genetics. In the same way that understanding the availability of genetic variance within populations requires the simultaneous consideration of genetic variance in sets of functionally related traits, determining how genetic variance changes under selection i...

Evolution of Genetic Variance-Covariance Structure

One of the features of organisms that makes the study of biology so compelling is their apparent complexity. Molecular, cellular, developmental, physiological, neurological, and behavioral systems are each fascinating in and of themselves, but it is their interaction that generates what we see as the organism as a whole. By necessity, biologists have a tendency to break down organisms into thei...